Fig. 9: The effects of MT depolymerization in αMHC-MCM-Fktn-cKO (Fktnflox/flox; αMHC-MCM+/−) hearts. | Nature Communications

Fig. 9: The effects of MT depolymerization in αMHC-MCM-Fktn-cKO (Fktnflox/flox; αMHC-MCM+/−) hearts.

From: Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure

Fig. 9

a Schedule of tamoxifen administration, colchicine treatment, and sample collection. Blue letters show the dose of colchicine. b Cardiac morphology (scale bar, 5 mm). c Masson’s trichrome staining of the left ventricle (scale bar, 50 μm). Cardiac function in tamoxifen-treated αMHC-MCM-Fktn-cKO hearts treated with colchicine (d) and survival percentages (e) (n = 10 per group). *P < 0.05 vs. tamoxifen-treated αMHC-MCM-Fktn-cKO mice based on Student’s t-tests.

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