Table 1 Patient characteristics.

From: A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2

Patienta

PS

HLA-A type

Peptide

Prior therapy

ELISPOT (CTL)

CTL induction

Mo

R1

R2

R1

R2

Case 1

3

2402/3303

2402

Surgery (bil. ves. sch), Rad (bil. ves. sch)

0

1+

+

+

3

NT

NT

6

3+

3+

Case 2

1

2402/3101

2402

Surgery (bil. ves. sch), Rad (Lt. ves. sch)

0

+

+

3

1+

6

1+

12

3+

Case 3

1

2402/0201

2402

Surgery (bil. ves. sch)

0

+

+

3

3+

2+

6

3+

3+

12

2+

18

3+

3+

Case 4

1

2402/3101

2402

Surgery (Rt. ves. sch)

0

1+

+

+

3

NT

NT

6

3+

3+

12

3+

3+

Case 5

1

0207/0301

0201

Surgery (FB Men)

0

1+

1+

+

3

2+

6

1+

1+

Case 6

1

2402/2420

2402

Surgery (C1), Rad (Lt. ves.sch), Beva

0

2+

1+

+

+

3

3+

2+

6

1+

1+

Case 7

1

0206/2602

0201

Surgery (Rt. ves. sch)

0

2+

+

+

3

3+

6

3+

  1. Bev bevacizumab, bil bilateral, CTL cytotoxic T lymphocyte, ELISPOT enzyme-linked immunospot, F female, FB frontal base, Lt left, M male, Men meningioma, Mo months after the first vaccination, NT not tested, PS performance status, Rad radiosurgery, R1 vascular endothelial growth factor receptor 1, R2 vascular endothelial growth factor receptor 2, Rt right, sch schwannoma, ves vestibular
  2. aAlthough four cycles of Bev were administered 3 years before the first vaccination, tumor growth was not regulated