Table 1 Variants associated with heart failure at genome-wide significance.

rsID	Chr	Position (hg19)	Nearest gene(s)^a	Function	Risk/ref allele	RAF (%)	OR (95% CI)	P value	I²_HET	P_HET
rs660240	1	109817838	CELSR2	UTR3	C/T	0.79	1.06 (1.04–1.08)	3.25E-10	0	0.513
rs17042102	4	111668626	PITX2, FAM241A	Intergenic	A/G	0.12	1.12 (1.09–1.14)	5.71E-20	43.1	0.008
rs11745324	5	137012171	KLHL3	Intronic	G/A	0.77	1.05 (1.03–1.07)	2.35E-08	5.7	0.381
rs4135240	6	36647680	CDKN1A	Intronic	T/C	0.66	1.05 (1.03–1.07)	6.84E-09	43.8	0.009
rs55730499	6	161005610	LPA	Intronic	T/C	0.07	1.11 (1.08–1.14)	1.83E-11	21.1	0.164
rs140570886	6	161013013	LPA	Intronic	C/T	0.02	1.24 (1.16–1.3)	7.69E-11	24.8	0.133
rs1556516	9	22100176	9p21/CDKN2B-AS1	ncRNA	C/G	0.48	1.06 (1.05–1.08)	1.57E-15	12.8	0.269
rs600038	9	136151806	ABO, SURF1	Intergenic	C/T	0.21	1.06 (1.04–1.08)	3.68E-09	0	0.729
rs4746140	10	75417249	SYNPO2L, AGAP5	Intergenic	G/C	0.85	1.07 (1.05–1.09)	1.10E-09	9.7	0.319
rs17617337	10	121426884	BAG3	Intronic	C/T	0.78	1.06 (1.04–1.08)	3.65E-09	55	2.1E-4
rs4766578	12	111904371	ATXN2	Intronic	T/A	0.47	1.04 (1.03–1.06)	4.90E-08	10.6	0.308
rs56094641	16	53806453	FTO	Intronic	G/A	0.42	1.05 (1.03–1.06)	1.21E-08	17.4	0.215

The table shows the 12 independent variants associated with HF at the genome-wide significance level (P < 5 × 10⁻⁸) in the meta-analysis of 29 studies. Meta-analyses were carried out using an IVW fixed-effect approach. The I²_HET describes the percentage of variation across the 29 studies that is due to heterogeneity. P_HET was derived from a Cochran’s Q-test (two-sided) for heterogeneity
Chr, chromosome; ncRNA, non-coding RNA; ref, reference; RAF, risk allele frequency; OR, odds ratio; CI, confidence intervals; HET, heterogeneity; I², I-squared
^aNearest gene with a functional protein or RNA (e.g., anti-sense RNA) product that either overlaps with the sentinel variant, or for intergenic variants, the nearest genes up- and downstream, respectively (separated by comma)

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