Fig. 1: Sonogashira-type enantioselective oxidative cross-coupling of C(sp3)−H bonds with terminal alkynes. | Nature Communications

Fig. 1: Sonogashira-type enantioselective oxidative cross-coupling of C(sp3)−H bonds with terminal alkynes.

From: Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp3)−H bonds with alkynes

Fig. 1: Sonogashira-type enantioselective oxidative cross-coupling of C(sp3)−H bonds with terminal alkynes.The alternative text for this image may have been generated using AI.

a Previous ionic-type dehydrogenative coupling of C(sp3)—H bonds adjacent to nitrogen. b Our proposal: tandem HAA and copper-catalyzed Sonogashira-type coupling. c Amide-directed enantioselective coupling of C(sp3)−H bonds with terminal alkynes. HAA hydrogen atom abstraction, [ox] oxidant, SET single-electron transfer.

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