Fig. 3: Substrate scope of N-fluorocarboxamides. | Nature Communications

Fig. 3: Substrate scope of N-fluorocarboxamides.

From: Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp3)−H bonds with alkynes

Fig. 3: Substrate scope of N-fluorocarboxamides.The alternative text for this image may have been generated using AI.

a The reaction is compatible with a variety of (hetero)aryl-fused N-fluorocarboxamide substrates. b Linear N-fluorocarboxamides are also applicable under slightly modified conditions. aStandard conditions: 1 (0.2 mmol), alkyne (0.4 mmol), CuI (10 mol%), L5 (10 mol%), and Cs2CO3 (1.0 equiv.) in THF (2.4 mL) at rt for 16 h. bIsolated yield based on 1. cEe values based on HPLC analysis. dL6 (10 mol%) was used in DCM at rt for 24 h. eL7 (Table 1, 10 mol%) was used in CHCl3 at rt for 24 h.

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