Table 3 Median viral load (VL) in clustered and nonclustered individuals with HIV diagnosed at stage 1 infection in people with drug-resistant virus, United States.

From: Natural selection favoring more transmissible HIV detected in United States molecular transmission network

DRAM

# Cases

Median VLa

Clustered

Nonclustered

ΔLog10 VLb

p valuec

# Cases (%)

Median VLa

# Cases (%)

Median VLa

L90M

80

20,992

39 (48.8%)

26,100

41 (51.3%)

11,200

0.367

0.003

K103N

674

20,939

286 (42.4%)

24,884

388 (57.6%)

18,300

0.133

0.033

NRTIs

260

11,436

69 (26.5%)

15,250

191 (73.5%)

10,533

0.161

0.075

Wild-typed

5914

18,700

2787 (47.1%)

22,517

3127 (52.9%)

16,330

0.140

<0.001

  1. aFirst reported VL (copies/ml) three months prior to or one-month post genotyping
  2. bDifference in median VL between clustered and nonclustered cases (not adjusted for epidemiologic and laboratory covariates)
  3. cSignificance of association between clustering and log10 VL linear regression for individuals with DRAM(s) in linear regression model
  4. dWild-type virus containing no DRAMS showing same results as in shown Table 1 for individuals with HIV diagnosed during stage 1 infection