Fig. 3: Cellular response to known and new environmental stimuli.

a An example depicting the phenotype transition CT→CTmvp: first, for a given sample changes for two example pathways (DNA replication and B cell receptor signaling pathways) and their corresponding genes were plotted over time. The lower panel show the activity distributions of the two example pathways obtained from the set of samples from each location. Simulation showed that the exploratory behaviors of both pathways differ from the intrinsic behaviors, therefore indicating that new adaptive pathway activities are due to the exploratory ability. b Following the calculations in sub-plot A, global distance per sample, together with the number of converged pathways were calculated over time. Light blue color represents individual samples’ temporal phenotype distances, and the dark blue line represents the mean value of that global distance. Initial D (t = 0) was set to 0.1, and the distance (t = 1000) reached 13.83, while number of converged pathways was reached to 33.4% on that time step. c Simulation results of the updated location-based phenotypes were re-calculated to include exploratory capacity (dJ > 0). Black color with a plus sign denote weights that are different from those of the intrinsic behaviors (dJ = 0) (intrinsic behavior is marked with gray lines).