Table 3 Summary of the heritability estimates of the four-variance component models.

From: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

  

Mean

Median

Range

Lipids and lipid-like molecules

h2total estimate

0.47

0.47

(0.11–0.66)

h2total s.e.

0.04

0.03

(0.02–0.07)

h2Metabolite-hits estimate

0.06

0.06

(−0.05–0.16)

h2Metabolite-hits s.e.

0.03

0.03

(0.01–0.04)

h2Class-hits estimate

0.06

0.06

(−0.02–0.16)

h2Class-hits s.e.

0.02

0.02

(0.01–0.03)

h2Notclass-hits estimate

0.00

0.01

(−0.06–0.12)

h2Notclass-hits s.e.

0.02

0.02

(0.01–0.03)

Organic acids and derivatives

h2total estimate

0.41

0.40

(0.14–0.72)

h2total s.e.

0.04

0.03

(0.02–0.07)

h2Metabolite-hits estimate

0.01

0.02

(−0.08–0.11)

h2Metabolite-hits s.e.

0.02

0.02

(0.01–0.04)

h2Class-hits estimate

0.01

0.01

(−0.04–0.14)

h2Class-hits s.e.

0.02

0.02

(0.01–0.03)

h2Notclass-hits estimate

0.00

0.00

(−0.06–0.05)

h2Notclass-hits s.e.

0.02

0.02

(0.01–0.03)

  1. The mean, median, and range of the total heritability (h2total), heritability based on the 479 significant metabolite loci for the 309 lipids or the 397 significant metabolite loci for the 52 organic acids (h2Class-hits), the 596–683 significant metabolite loci not belonging to these classes (h2Notclass-hits) and the total heritability explained by metabolite loci (e.g., sum of h2Class-hits and h2Notclass-hits: h2Metabolite-hits), as well as their standard errors (s.e.’s), are depicted for all 361 successfully analyzed metabolites as included on all platforms. Supplementary Data 2 denotes which metabolites belong to each class and Supplementary Data 3 provides the estimates for each of the individual metabolites