Table 2 Predictive connections of the RPN signature.

Predictive connections between brain regions						Weight
Region	RSN	idx	region	RSN	idx	Weight
PO/pSTG	VAN + SN + BG + Thal	119	pPut	VAN + SN + BG + Thal	25	0.270
FP	FPN	75	5	CER	48	0.245
pCVI	CER	9	SMC	VAN + SN + BG + Thal	28	−0.200
R aCrus2	CER	62	lPrCG	SMN	93	0.150
dPrCG	SMN	67	pmVN	VN	51	−0.102
pdlVN	VN	43	mVN	VN	40	0.095
L IPL	DMN	114	mean GM	mean GM	–	−0.086
vCaud	VAN + SN + BG + Thal	2	plVN	VN	39	0.085
Acc	MLN	78	pvmVN	VN	107	−0.073
CF	MLN	79	vlPrCG	SMN	110	−0.062
5	CER	48	pdlVN	VN	43	−0.059
pThal/Hb	VAN + SN + BG + Thal	36	plVN	VN	39	0.058
dCVI	CER	44	lOTG	FPN	117	−0.057
dCiX	CER	11	L vMFG	FPN	105	−0.056
R IPS	FPN	20	plVN	VN	39	−0.054
avIns	VAN + SN + BG + Thal	12	admVN	VN	19	−0.044
R aMFG	FPN	58	lPoCG	VAN + SN + BG + Thal	102	0.043
CrusI	CER	84	dPoCG	VAN + SN + BG + Thal	116	−0.017
pgACC	DMN	115	mSTG	VAN + SN + BG + Thal	88	0.009
Precun	DMN	103	LOG	MLN	109	−0.003
vThal	VAN + SN + BG + Thal	36	FEF	VAN + SN + BG + Thal	113	−0.001

Non-zero regression coefficients naturally delineate the predictive sub-network. Regions and corresponding large-scale resting-state network (RSN) modules are to be interpreted as in the MIST atlas (see Methods, original atlas-index is given). Predictive connections are ordered by their absolute predictive weights. Connectivity strengths associated with higher and lower sensitivity to pain are highlighted in red and blue, respectively. For bootstrapping-based 95% confidence intervals and the p-values with conditional coverage, see Supplementary Table 4
CER cerebellum, Roman numerals cerebellar lobes, GM grey matter, VAN ventral attention network, SN salience network, BG basal ganglia, Thal thalamus, Hb habenula, MLN mesolimbic network, FPN frontoparietal network, SMN somatomotor network, DMN default mode network, VN visual network, Ins insula, PO parietal operculum, SII secondary somatosensory cortex, STG superior temporal gyrus, FEF frontal eye-field, PrCG precentral gyrus, PoCG postcentral gyrus, SMC supplementary motor cortex, Put putamen, Caud caudate nucleus, Acc nucleus accumbens, LOG lateral orbital gyrus, CF collateral fissure, OTG occipitotemporal gyrus, MFG middle frontal gyrus, IPS intraparietal sulcus, pgACC perigenual anterior cingulate cortex, PrC precuneus cortex. L left, R right, a anterior, p posterior, v ventral, d dorsal, l lateral, m medial

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