Fig. 5: Distribution of induced tau pathologies in 6hTau mice.

a Neuroanatomic connectome map showing the anterograde and retrograde connections between the injection site (dorsal hippocampus) and other major brain regions. The distribution of the induced tau aggregates in 6hTau mice by different b AD; c PiD; d CBD, and e PSP tau strains were mapped and shown in five representative coronal brain sections at Bregma levels mm: −0.22, −1.22, −2.18, −2.92, −3.25. Neuropil threads were indicated using the heatmap, with gray color indicating no and red color indicating abundant neuropil threads. Neuronal tau pathologies are marked by blue dots, astrocytic tau pathologies are shown as red stars and oligodendrocyte tau pathologies are marked by purple dots. The density of the dots reflects the relative abundance of these tau pathologies. Injection sites are marked with black stars. Mice were examined at 1, 3, and 6 m.p.i., and each group contained 3–6 mice.