Fig. 7: Tau isoform compositions in the induced glial pathologies.

Representative IHC staining of induced (a) oligodendrocytic and d astrocytic tau pathologies induced in 6hTau mice injected with P0- and P1-tau as shown in Fig. 2b and d using AT8, RD3, and RD4 antibodies on adjacent brain sections. Quantification of induced oligodendrocytic tau pathologies in b strain_P0- and c strain_P1–6hTau mice. Quantification of induced astrocytic tau pathologies in e strain_P0- and f strain_P1-6hTau mice. n = 3–6 mice per group were quantified, and multiple t-test were performed. g representative IHC staining and h quantification of oligodendrocytic tau pathologies in PSP_4R-6hTau mice as shown in Fig. 4d. n = 3 mice per group were quantified, and multiple t-test were performed. Quantifications were from ipsilateral brain side (i) of each mouse. Data are presented as mean ± s.e.m. Significant differences were considered when p ≤ 0.05. WM white matter, Fim fimbria, Hpx hippocampus. Solid arrowheads indicate oligodendrocytic pathologies, and dashed circles indicate astrocytic pathologies. Source data is available as a Source Data file.