Table 1 Binding kinetics of ligelizumab and omalizumab variants for human IgE.

From: The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab

Anti-IgE antibody

Association ka (M−1s−1)

Dissociation kd (s−1)

Affinity KD (pM)

Ligelizumab IgG

1.8 × 106

3.3 × 10−5

17.8

Omalizumab IgG

9.1 × 105

2.4 × 10−3

2659

Ligelizumab F(ab′)2

4.2 × 106

5.1 × 10−5

12.1

Omalizumab F(ab′)2

8.7 × 105

2.6 × 10−3

2998

Ligelizumab Fab

9.2 × 106

3.2 × 10−4

35.0

Omalizumab Fab

1.5 × 106

4.6 × 10−3

3090

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