Fig. 1: Study design and data integration. | Nature Communications

Fig. 1: Study design and data integration.

From: Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits

Fig. 1: Study design and data integration.The alternative text for this image may have been generated using AI.

We conducted an EWAS with proteomics in KORA and replicated the associations in QMDiab (see Fig. 2). We used Ingenuity Pathway Analysis (IPA) to connect CpG-linked genes to their associated proteins through literature-reported observations and complemented the network with associations to gene expression (BIOS), metabolomics (QMDiab), and clinical endpoints (KORA), finally adding all previously reported disease associations. The resulting networks, using the same color code as here, are presented in Figs. 3 and 4.

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