Fig. 8: Implication for drug design specific to tbNadE.
From: Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+ synthetases
a Overlay of tbNadE and hsNadE complexes. NaAD+ shown with AMP in hsNadE in cyan and SFIs in tbNadE in gray (PPis are omitted for clarity). The P2 loop residues are pink and light pink in hsNadE and tbNadE, respectively. Residues important for future anti-TB drug design are shown as sticks. Pink and cyan arrows highlight the residue with the biggest difference in size and/or character between homologs. b–e Comparison of the synthetase-binding site between homologs at α14 and the Lg loop (b), P2 loop (c), α20 (d), and α13 (e).
