Fig. 7: Variable contribution of infused CAR-T clusters to in vivo repertoire. | Nature Communications

Fig. 7: Variable contribution of infused CAR-T clusters to in vivo repertoire.

From: Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

Fig. 7

a t-SNE plot showing the localization of IRF clonotypes (red) and DRF clonotypes (blue) in the IP (left) or at the early time point (right). Each dot represents a single CAR-T cell. b Heatmap displaying genes that are differentially expressed between IRF and DRF clones in the IP. Color scale represents gene expression levels as a z-score. c Pie charts depict the fraction of IRF or DRF clonotypes that are distributed among the four transcriptionally distinct clusters in the IP. The percent of cells in cluster 2 and 4 among IRF clonotypes are reported. d Bars depict the fraction of transcriptionally distinct clusters among CD8+ CAR-T cells in the IP that were either detected (Yes) or not detected (No) at the early (Left), late (Middle), or very late (Right) time points after infusion. Source data are provided as a Source Data file.

Back to article page