Fig. 2: SVs associated with TERT and its increased expression.

a Circos plot showing all intra- and interchromosomal rearrangements 0–100 kb from the TERT locus. b By cancer type, SV breakpoint locations within the region ~100 kb upstream of TERT. Curved line connects two breakpoints common to the same SV. TERT promoter, CpG Islands, and CTCF and Myc binding sites along the same region are also indicated. c Gene expression levels of TERT corresponding to SVs with breakpoints located in the genomic region 0–20 kb downstream to 100 kb upstream of the gene (116 SV breakpoints involving 47 cases). d Where data available, gene expression levels of TERT corresponding to SVs from part (b). Expression levels associated with TERT promoter (PM) mutation are also represented. Median expression for unaltered cases represents cases without TERT alteration (SV, promoter mutation, amplification, viral integration) or MYC amplification. For part (d), where multiple SVs were found in the same tumor, the SV breakpoint that was closest to the TERT start site was used for plotting the expression. e Numbers of enhancer elements within a 0.5 Mb region upstream of each rearrangement breakpoint are positioned according to breakpoint location. For unaltered TERT, 21 enhancer elements were 0.5 Mb upstream of the gene. See also Supplementary Data 3.