Fig. 3: 5FC resistant mutants are cross-resistant to 5FU. | Nature Communications

Fig. 3: 5FC resistant mutants are cross-resistant to 5FU.

From: 5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

Fig. 3

a Isolates that were selected based on growth on 5FC media were patched to YNB, YNB plus 5FC, and YNB plus 5FU. Each plate has parental and fur1 mutant controls in the top row. Hypermutator controls have occasional resistant colonies that emerged in the growth patch. Sanger and Illumina sequencing revealed that 12 of 29 isolates had sustained mutations in FUR1. b Schematic showing the predicted domains encoded by the UXS1 gene, as well as the location and number of mutations identified. Frame-shift alleles are shown in red and missense are shown in blue.

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