Fig. 3: VAF-based clonal evolution analysis and allele burden quantification in flow-sorted cell fractions.
From: Single-cell analysis based dissection of clonality in myelofibrosis
a Mutations clustered by VAF generated from ultra-deep sequencing at various follow-up time points. Disease-defining mutations in JAK2/CALR are depicted independently to emphasize their specific role in disease pathogenesis. From each cluster representative mutated genes were selected. b Representative mutation distribution in different blood lineages. Patients with differential segregation of mutations are displayed. Bar color correspond to respective clones shown in a. Source data are provided as a Source Data file.
