Fig. 8: Increased adipose Ogt/Oga ratio is a molecular signature of impaired whole-body metabolism in mice and obesity and diabetes in humans.

a Correlation between the ratio of white fat Ogt/Oga transcript levels and serum free fatty acid (FFA) levels in 41 different mouse strains from the GeneNetwork database (the EPFL LISP3 Cohort); NC-fed and HFD-fed male mice at the fasted state were used for the analysis. b Correlation between the ratio of white fat Ogt/Oga transcript levels and glycemia during oral glucose tolerance test (glucose AUC); mice described in a were used. c, d Correlations between ratios of Ogt/Oga transcript levels (full-length transcripts) in human subcutaneous fat (Sub.) and visceral fat (Vis.) and body mass index (BMI); data from men and women were used for the analysis; original raw data was from the GTEx database (dbGaP study accession: phs000424.v7.p2) (n = 441 for c; n = 356 for d). e, f The average ratio of Ogt/Oga transcripts in subcutaneous fat (Sub.) and visceral fat (Vis.) of human subjects diagnosed with type 2 diabetes (T2D) and non-diabetic normal controls (n = 348 normal, 91 T2D for e; n = 286 normal, 68 T2D for f); data were obtained from the same study described in c, d. Data are presented as mean ± s.e.m. Statistical analysis: Student’s t test for e, f and linear regression for the other panels. Source data are provided as a Source Data file.