Fig. 6: Hr10 inhibits thrombosis without causing bleeding. | Nature Communications

Fig. 6: Hr10 inhibits thrombosis without causing bleeding.

From: Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

Fig. 6

a Graphs showing kinetics of human platelet accumulation at nascent laser-induced injury sites in cremaster muscle, 5 min following infusion of PBS or equimolar amounts of Hr10 or eptifibatide in the same buffer. Values represent the mean + s.e. of four mice per arm). There was no significant difference in human platelet accumulation in thrombi between Hr10- and eptifibatide-treated mice at each time point. b Histograms (mean + s.e.) showing baseline bleeding volume in vWFRH/RHNSG mice infused with human platelets before (PBS; n = 6) or after administration of eptifibatide (Epti.; n = 4), or Hr10 (n = 4). Epti. caused excessive loss of blood (~10% of blood volume of a normal mouse), which was absent in Hr10-treated mice. Difference between PBS- and Hr10-treated mice was not significant (p = 0.94, Student’s t-test, two-tailed). The other p values are shown.

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