Fig. 1: Overview structures of CV-A10 and its receptor complex.
From: Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
Radially coloured surface representations of mature CV-A10 virus (a), CV-A10/KRM1 complex (b) and expanded CV-A10 A-particle (c). The first ordered residue of the VP1 N-terminus is coloured in magenta showing where it externalizes in c. Electron potential maps at icosahedral twofold axis of the mature CV-A10 (d), CV-A10/KRM1 complex (e) and CV-A10 A-particle (f). CV-A10/KRM1 interacting across the canyon from above (g) where a virus pentamer is drawn as a grey surface with one icosahedral pentameric subunit coloured with VP1 blue, VP2 green and VP3 red. KRM1 is drawn as a cartoon with the domains colour coded: KR magenta, WSC orange, CUB grey, adjacent receptors are colour coded in grey. Interaction of one virus protomer with KRM1 from the side closest to the KR domain (h), virus and receptor drawn as a cartoon keeping the same colours as in g. Interaction of one virus protomer with KRM1 from the side closest to the WSC domain (i), drawn as for h.
