Fig. 5: Comparison of amino acids in the receptor attachment area of CV-A10 strains and with other enteroviruses that cause HFMD.
From: Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
a Residues in 14 strains of CV-A10 are highly conserved (33 out of 37) and 6 of the 31 residues are conserved among the KRM1-dependent type A enteroviruses, these are K140 and P141 in VP2 EF loop, G181, G182 and D185 in the VP3 GH loop, and Q240 at the C-terminus of VP3. Only one residue VP3 Q240 is conserved among 19 HFDV causing enteroviruses. KRM1 is shown as an electrostatic surface, residues of CV-A10 involved in contacts are shown as sticks with the same colour scheme as Fig. 3d, except the non-conserved sidechains are in grey. b Roadmap depiction of the virus surface (see “Methods” section). An icosahedral subunit is outlined in black lines and residues from VP1 are shown in blue, VP2 green and VP3 red with those in contact with KRM1 highlighted in the corresponding protein colour. Residues in contact with KRM1 and around the icosahedral symmetry axis are labelled.
