Fig. 4: TCR repertoire diversity of MAIT cells before and after acute HIV-1 infection.
From: Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection
RNA-Seq was performed on sorted MAIT cells from PBMC samples at pre-infection and early chronic post-infection time points in the acute capture cohort (n = 6). a TCRα and TCRβ clonal sequence diversity of MAIT cells before and after HIV-1 infection in one representative donor. b Change in the number of MAIT cell TCRα and TCRβ clones detected before and after HIV-1 infection. *p < 0.05, Wilcoxon Signed Rank test. MAIT cells are identified as CD161++Vα7.2 + cells within CD3+CD14-CD19- live lymphocytes. Donors analyzed here are a subset of donors analyzed in Fig. 2. Post-infection time point corresponds with early chronic HIV infection (85 days since first positive test for HIV-1 RNA).
