Fig. 3: rDNA resection occurs downstream of ATR activation.
From: Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
a Timecourse of RPA2 foci formation in U2OS cells after I-Ppo1 transfection. b Timecourse of RPA2 foci formation in cells counterstained for Cyclin A. c Quantification of the experiment in b (all data points shown, red bars represent mean). d Timecourse of RPA2 foci formation in U2OS WT and NBS1ΔN cells after I-Ppo1 transfection. e Quantification of the experiment in d (all data points shown, red bars represent mean). f Timecourse of RPA2 foci formation in U2OS cells treated with ATMi (KU-55933) and ATRi (VE-821) after I-Ppo1 transfection. g Quantification of the experiment in f (all data points shown, red bars represent mean). All scalebars = 10 µm. Source data are provided as a Source Data file.
