Fig. 2: Correlation of osteoclast and osteoblast genes and secreted factors altered by DMAb. | Nature Communications

Fig. 2: Correlation of osteoclast and osteoblast genes and secreted factors altered by DMAb.

From: Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Fig. 2: Correlation of osteoclast and osteoblast genes and secreted factors altered by DMAb.

a Heat maps showing the osteoclast and osteoblast normalized gene expression in placebo and DMAb-treated participant bone biopsies. Normalized gene expression (CQN values) were ranked for each gene across the placebo and DMAb participant biopsies (N = 15 participant biopsies/group). Red denotes higher expression and blue denotes lower expression. b Rank mean values for DMAb-suppressed osteoclast and osteoblast gene sets were plotted for the placebo participants. c DMAb-suppressed secreted factor genes, but not d DMAb-upregulated secreted factor genes correlate with osteoblast and osteoclast marker genes in the placebo participants (N = 15 participant biopsies); Spearman’s correlation coefficient was used to test the strength of the relationship between rank mean gene sets in b–d. Source data are provided as a Source Data file.

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