Fig. 4: KDM6s deficiency decreases chromatin accessibility in hNPCs.
From: JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells
a Heatmap of up- or downregulated genes in dKO NPCs and wild-type (WT) NPCs at passage 2. b, c Top 15 GO terms most enriched in genes upregulated or downregulated in dKO NPCs. d Left panel, heatmap of ATAC-seq data indicating differentially accessible chromatin regions between WT NPCs and dKO NPCs. Right panel, top 15 GO terms most enriched in genes associated with decreased and increased chromatin accessibility in dKO NPCs. OC, open-to-closed, indicates regions with reduced chromatin accessibility in dKO NPCs. CO, closed-to-open, indicates regions with increased chromatin accessibility in dKO NPCs. e The numbers of OC or CO regions described in d. f ATAC-seq analysis of downregulated and upregulated genes in dKO NPCs and WT NPCs. g Genomic views of selected genes in WT NPCs or dKO NPCs from ATAC-seq data. These selected genes include those with functions of NPC proliferation, neuron development markers, NOTCH pathway genes and genes with increased chromatin accessibility in dKO NPCs. h, i Top 10 motifs most enriched over the OC or CO regions described in d.
