Fig. 7: Golgi organization is regulated by proteasomal degradation.

Proteasomes are constitutively associated with the Golgi membranes and mediate the degradation of the Golgi tethering protein GM130. Golgi-apparatus related degradation (GARD) is activated in response to Golgi-stress, such as block of sialylation by LCG, and induces enhanced degradation of GM130, leading to dispersal of the Golgi apparatus, upregulation of CHOP, and cell death. Accurate morphology of the Golgi may be retained upon relief of the stress (dotted line), suggesting that proteasome-dependent control of Golgi organization might serve as a cell-fate dictating mechanism during the stress-response.