Fig. 6: Dereplication of known compounds and predicted secondary metabolite backbone genes per species.

a A dendrogram representing the phylogenetic relationship between the species. The black boxes in the nodes represent the secondary metabolite gene cluster (SMGC) families shared among the species branching from that node. If there is no black box there are zero clusters shared. The gray boxes at the tips show the number of unique SMGC families only found in one species for the Flavi section. b Matrix indicating the presence and absence of SMGC families coupled to known clusters from the MIBiG database⁶⁶ for each species. Overview of the cluster family for aflatoxin can be found in Supplementary Figure 11. c Predicted secondary metabolite genes for each species divided by the backbone enzyme. DMAT: dimethylallyltransferase (prenyl transferases), HYBRID: a backbone gene containing domains from NRPS and PKS backbones, NRPS: non-ribosomal peptide synthetase, NRPS-like: non-ribosomal peptide synthetase like, containing at least two NRPS-specific domains and another domain or one NRPS A domain in combination with NAD binding 4 domain or short-chain dehydrogenase, PKS: polyketide synthase, PKS-like: polyketide synthase like, containing at least two PKS-specific domains and another domain, TC: terpene cyclase.