Fig. 3: High-confidence germline-related prognostic modules (GRPMs).
From: A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
The GRPM is shown at the center of the circles, surrounded by the biological processes enriched among the downstream transcriptional effects of each module. Three modules were found for estrogen receptor (ER)-negative breast cancer (a–c) and one module was found for ER-positive breast cancer (d). a G-alpha signaling GRPMs. b Circadian clock GRPM. c Regulators of cell growth and angiogenesis GRPM. d Rho GTPases and apoptosis GRPM. e Plots illustrating the association between each GRPM’s PHS and 10-year breast cancer specific-survival in the discovery and independent sets. HR hazard ratio (per standard deviation of the PHS), CI confidence interval. The error bars show the 95% confidence interval. The confidence intervals shown are two sided, whereas the significance test performed was one sided (see “Methods”).
