Fig. 4: Genomic region 19p13.3 with the two genes GNA11 and GNA15.
From: A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
The two G-alpha signaling high-confidence germline-related prognostic modules (GRPMs) identified in the estrogen receptor (ER)-negative subtype have a shared genetic signal in the same genomic region. a Top: −log10(P) for the association with survival (y axis) of all variants in the region 19p13.3 (y axis). Bottom: regression coefficients from the survival model for the genetic variants in the module’s polygenic hazard scores (PHSs). b Scatter plot comparing the two modules’ PHSs in the iCOGS independent validation set. PHS of the GNA11 GRPM on the x axis and PHS of the GNA15 GRPM on the y axis.
