Fig. 2: P-crAssphage populations in mothers and infants differ in strain diversity.
From: Acquisition, transmission and strain diversity of human gut-colonizing crAss-like phages
a The p-crAssphage population in mothers has more multiallelic sites than the p-crAssphage population in infants. Fmulti (fraction of the p-crAssphage genome with multiallelic sites detected at the given allelic fraction threshold) in all mother and infant samples with at least one multiallelic site detected. P-values were calculated with the two-sided Wilcoxon rank-sum test and are uncorrected for multiple hypothesis testing. b P-crAssphage populations in mothers do not change in the number of multiallelic sites over time. Fmulti for mother samples from Yassour et al.16. P-values were calculated with a linear mixed model to account for repeated sampling of the same individual. c Allelic fraction of multiallelic sites in the p-crAssphage genome from mothers that are fixed in her infant. The distribution is separated by alleles that are present in the infant’s p-crAssphage or not. P-values were calculated with the two-sided Wilcoxon rank-sum test. d Schematic depicting multiallelic sites in mother and infant samples over time. In the three cases where p-crAssphage was detected in the mother and multiple samples from the same infant, infants develop more multiallelic sites over time. Additional examples of multiallelic sites in mothers and infants are provided in Supplementary Fig. 10. In all boxplots, boxes extend to the first and third quartile, whiskers extend to the upper and lower value within 1.5* interquartile range (IQR) from the box. Outliers are shown as points.
