Fig. 1: Sequence variants associating with asthma. | Nature Communications

Fig. 1: Sequence variants associating with asthma.

From: Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis

Fig. 1: Sequence variants associating with asthma.The alternative text for this image may have been generated using AI.

Manhattan plot for the Iceland-UK BB meta analyses of asthma (Ncases = 69,189). In all, 56 regions harbor genome-wide significant signals. Variants are plotted by chromosomal position (x-axis) and −log10P values (y-axis). Dotted line indicate the different P value thresholds applied based on variant annotation. The adjusted significance thresholds are represented by horizontal dashed line from bottom to the top in the following order: 2.6 × 10−7 for variants with high impact (N = 8,464), 5.1 × 10−8 for variants with moderate impact (N = 149,983), 4.6 × 10−9 for low-impact variants (N = 2,283,889), 2.3 × 10−9 for other variants in DNase I hypersensitivity sites (N = 3,913,058) and 7.9 × 10−10 for all other variants (N = 26,108,038).

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