Fig. 3: S47 mice are more susceptible to Listeria infection than WT mice. | Nature Communications

Fig. 3: S47 mice are more susceptible to Listeria infection than WT mice.

From: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

Fig. 3

a S47 P47 or R72 mice were infected with Lm and monitored daily from day 2 post infection by CFU and b survival (n = 10 biological replicates). Error bars represent means ± s.e.m. ***P < 0.001, *P < 0.05, ns—not significant; by unpaired Student’s t test, relative to P47 mice. c Bacterial load in different organs at the time of death measured as CFU/gm (n = 7–10 biological replicates with three technical replicates). Right panel compares changes in bacterial load in P47 & S47 mice following DFO treatment. Error bars represent means ± s.e.m. P < 0.01, *P < 0.05, ns—not significant; by unpaired Student’s t test, relative to P47 mice. d Spleens of P47 and S47 mice at 13 days post infection. Bar = 1 cm. Source data are provided as a Source Data file.

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