Fig. 3: Mediation analysis.

The association between EDA2R and gf was a significantly partially mediated (31%) by total brain volume in LBC1936. Indirect effect (a × b) = −0.048, p < 0.001. b Significantly partially mediated (36%) by brain MRI variables in LBC1936. Indirect effect (a × b) = −0.059, p < 0.001.