Table 4 Mediation of association between protein–PC1 and proteins and general fluid cognitive ability by total brain volume in LBC1936.

Protein	Total beta	Total SE	Total P	Total brain vol IDE beta	Total brain vol IDE SE	Total brain vol IDE P	% attn	c′
EDA2R	−0.157	0.04	<0.001	−0.048	0.012	<0.001	30.57	−0.109
PVR	−0.173	0.04	<0.001	−0.028	0.011	0.009	16.18	−0.145
EFNA4	−0.135	0.041	0.001	−0.027	0.011	0.015	20.00	−0.108
DDR1	−0.138	0.04	0.001	−0.01	0.01	0.35	7.25	−0.128
RSPO1	−0.141	0.041	0.001	−0.02	0.011	0.057	14.18	−0.121
SKR3	−0.126	0.041	0.002	−0.036	0.012	0.002	28.57	−0.090
TNFRSF12A	−0.114	0.04	0.005	−0.027	0.011	0.014	23.68	−0.087
VWC2	−0.124	0.04	0.002	−0.01	0.01	0.354	8.06	−0.114
Siglec-9	−0.143	0.04	<0.001	−0.014	0.01	0.184	9.79	−0.129
SCARB2	−0.131	0.041	0.002	−0.033	0.011	0.004	25.19	−0.098
LAYN	−0.121	0.041	0.003	−0.026	0.011	0.019	21.49	−0.095
UNC5C	−0.101	0.04	0.012	−0.015	0.011	0.147	14.85	−0.086
CLM-6	−0.12	0.04	0.003	−0.026	0.011	0.055	21.67	−0.094
CPM	−0.116	0.04	0.004	−0.006	0.01	0.56	5.17	−0.110
MSR1	−0.106	0.039	0.007	−0.038	0.011	0.001	35.85	−0.068
Protein–PC1	−0.113	0.04	0.005	−0.01	0.01	0.334	8.85	−0.103
N2DL-2	−0.11	0.04	0.006	−0.019	0.011	0.079	17.27	−0.091
GFR-alpha-1	−0.106	0.041	0.009	−0.031	0.011	0.006	29.25	−0.075
SIGLEC1	−0.12	0.04	0.003	−0.028	0.011	0.011	23.33	−0.092
CDH6	−0.091	0.04	0.023	−0.006	0.01	0.572	6.59	−0.085
THY1	−0.105	0.041	0.01	−0.017	0.011	0.118	16.19	−0.088
SCARA5	−0.096	0.041	0.018	−0.004	0.011	0.722	4.17	−0.092
PLXNB1	−0.079	0.041	0.052	−0.012	0.011	0.277	15.19	−0.067

Corrected for age and sex. Total effect sizes (total betas) differ from those in Table 3 as the mediation analysis included fewer individuals. Significant mediations (FDR corrected) are indicated in bold.
IDE indirect effect, % attn percentage attenuated.

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