Fig. 9: CD47-activating peptide treatment alters the transcriptional profile of macrophages.
From: Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
a Changes in cytokine and chemokine levels from homogenates in mice treated with PBS or p7N3 (CD47-activating peptide) 3 days after burn/tenotomy. Eotaxin: t = −5.838, df = 4, p = 0.004; LIF: t = −1.162, df = 4, p = 0.310; IL15: t = −2.550, df = 4, p = 0.063; CXCL1: t = −0.604, df = 4, p = 0.578; CCL2: t = −2.870, df = 4, p = 0.045; CCL3: t = −1.492, df = 2, p-0.274; CCL4: t = −0.218, df = 4, p = 0.838. b, c t-SNE dimensionality reduction analysis of single cell sequencing performed on cells from 1 week burn/tenotomy harvested from the site of extremity injury revealed 15 distinct cell clusters in both b PBS and c p7N3 (CD47) treated mice (representative performed in triplicate). Source data are provided as a Source Data file.
