Fig. 1: Phosphorylated α-Syn pathology in CNS segments of diseased α-Syn PFFs mice. | Nature Communications

Fig. 1: Phosphorylated α-Syn pathology in CNS segments of diseased α-Syn PFFs mice.

From: Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy

Fig. 1

a–f Representative immunohistochemical results displaying the distribution of pα-Syn pathology in the 3rd thoracic spinal cord (T3) (a), the 11th thoracic spinal cord (T11) (b), medulla (c), pons (lower) (d), pons (upper) (e) and midbrain (f). g Schematic displaying the distribution pattern of pα-Syn pathology in diseased α-Syn PFFs mice. Green, yellow, orange, and red represent the severity of α-Syn pathology, ranging from low densities to high densities of inclusions. h–s High-magnification immunohistochemical images in different CNS regions from diseased α-Syn PFFs mice show the pα-Syn inclusions in IML of T3 (h) and T11 (i), 7Sp of T11 (j), dorsal motor nucleus of vagus (k), ambiguus nucleus (l), solitary nucleus (m), locus coeruleus (n), Barrington’s nucleus (o), parvicellular reticular nucleus (p), periaqueductal gray (q), median raphe nucleus (r), and arcuate hypothalamic nucleus (s). [Scale bars, 500 µm (a–d); 1 mm (e, f); 66 µm (h–s)].

Back to article page