Fig. 2: Structure of the cA4 activator and interactions with Can1.
From: Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
a Divergent stereo representation of cA4 (in stick representation; carbon in yellow, nitrogen in blue, oxygen in red) with the maximum likelihood/σA weighted Fobs—Fcalc electron density map contoured at 3.0 sigma shown in red. b Divergent stereo representation of the binding site of cA4 in complex with Can1. cA4 (with each AMP numbered A1-A4) and binding site residues are shown in stick representation, with cA4 in yellow and amino acid residues coloured by the domain from which they originate (CARF domain 1: magenta, domain 2/nuclease-like domain: cyan, CARF domain 2: green, nuclease domain: orange). The dotted lines represent hydrogen bond interactions.
