Fig. 5: Conformational changes within TrkH. | Nature Communications

Fig. 5: Conformational changes within TrkH.

From: TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

Fig. 5

a–c Top: Surface representations (yellow) of the ion permeation pathways of TrkH from TrkHA-ADP (a), TrkHA-ATPγS (b), or TrkHA-ATP (c), plotted using the program HOLE16. Bottom: Stick representations of the selectivity filter and intramembrane loop in TrkH from TrkHA-ADP (a), TrkHA-ATPγS (b), or TrkHA-ATP (c). The 2Fo-Fc electron density maps are shown in blue meshes contoured at 1.0σ. d Radius of the ion permeation pathways, as calculated by HOLE16. e TrkH protomers from TrkHA-ADP (blue), TrkHA-ATPγS (orange), or TrkHA-ATP (red) rendered in ribbons superimposed at the selectivity filters, showing either the D1 and D3 domains (top) or the D2 and D4 domains (bottom). f–h Top: TrkH protomers from TrkHA-ADP (f), TrkHA-ATP (g), TrkHA-ATPγS (h), rendered in cylinders viewed from the periplasmic side. Bottom: TrkH protomers from TrkHA-ADP (f), TrkHA-ATP (g), or TrkHA-ATPγS (h) rendered in ribbons viewed within membrane. The D4M1 and D3M2b helices at the dimer interfaces are rendered in cylinders.

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