Fig. 9: Model of spontaneous and KJE-ATP assisted folding of FLuc. | Nature Communications

Fig. 9: Model of spontaneous and KJE-ATP assisted folding of FLuc.

From: Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein

Fig. 9: Model of spontaneous and KJE-ATP assisted folding of FLuc.

a MF, misfolded compact intermediate; Agg., aggregated protein; US, unfolded state in the absence of chaperones; IS, folding intermediate of spontaneous folding; UC, unfolded state in complex with DnaK; IC, intermediate committed to fast folding; N, native state. Lengths of arrows reflects approximate relative rates. b Simplified energy diagrams to illustrate the effect of KJE-ATP in stabilizing the native state of FLuc at elevated temperature by accelerating refolding of MF.

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