Fig. 4: The landscape of CNVs illustrate both focal and whole-chromosome events.
From: Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice
a CNVs across all sequenced (whole exome and whole genome) samples. Tumour samples are sorted by tissue site (large blocks separated by black lines) and subsequently by pathology, radiation quality and genotype status of Trp53. Relative copy number states across each chromosome are indicated by a corresponding key as shown at the lower right. Some chromosomes show predilection for whole-chromosomal amplification (e.g. Chromosome 5 and 15, the latter particularly in lymphomas) while other regions show more deletions (Chromosome 4) or focal amplifications (e.g., proximal Chromosome 6 corresponding to Met in mammary samples). b Circos plot illustrating relationships between amplification status, gene expression, translocations, and candidate driver genes across tumours induced by radiation exposure. From outside to inside: 1. Driver genes. 2. Cytoband map of the mouse chromosome. 3. Focal CNVs gains. 4. Focal CNVs losses. 5. Aneuploidy gains. 6. Mixed chromosome changes. 7. Aneuploidy losses. 8. Expression of cancer driver genes in tumour samples versus normal samples. 9. Intrachromosomal and interchromosomal translocations identified in samples that were subjected to whole-genome sequencing. Y-chromosome was not included in the analysis.
