Fig. 5: Focal amplification of Met is preferentially induced by 56Fe-ion radiation.
From: Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice
a Mammary tumours bear high frequency of focal amplifications on chr 6 (at the Met locus) predominantly in Fe-ion associated tumours. N = 42. b Focal analysis of the Met locus to illustrate that the same region with focal Met amplifications are co-enriched for structural variants. The highest frequency of structural variants (red vertical line) does not coincide exactly with the locus with the increased copy number of Met, suggesting that other selection mechanisms led to the high Met copy number. Locations of genes in the amplified region are shown in the lower panel. N = 21 (translocations from WGS data). N = 10 (expression from RNAseq data). c Higher expression of Met by whole transcriptome RNA-seq is strongly associated with copy number status. RNA from a total of 10 mammary tumours was sequenced. Expression is shown for tumours with or without Met amplification, as well as matched normal samples. Error bars = 95% confidence intervals. d Association between Met amplification and tumour site of origin (mammary, skin, lymphoma), histology and radiation quality.
