Fig. 6: Chromothripsis in radiation-induced tumours.
From: Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice
a Mapping of different somatic mutation types across chromosome 1 in all of the whole genome sequenced mammary tumours. Sub: Substitutions, ITX: Intrachromosomal translocation, INV: Inversion rearrangements, INS: Insertion rearrangements, DEL: Deletion rearrangements, CTX: Interchromosomal translocation, Ins: Small Insertions, Del: Small deletions, Complex: Complex INDELS. b Sample MD5207c has a strikingly large number of mutations of different types spread widely across the length of the chromosome, indicative of whole chromosome chromothripsis.
