Fig. 7: Interaction between Trp53 genotype and RT quality in complex structural variants.
From: Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice
a Three samples showing representative enrichment of SVs on chromosome 11 near the Trp53 locus, some with evidence of co-localisation of breakpoints and/or variants. Arrows denote the location of the Trp53 gene along chromosome 11. b Tumours from Trp53+/− mice show common non-focal deletions or whole-chromosomal aneuploidy in chr 11 (top panel). These large scale copy number alterations are less common in tumours from the Trp53ΔP mice (lower panels). Arrow denotes the location of Trp53. c Effect of Trp53 germline genotype on patterns of somatic alterations at the Trp53 gene in mammary tumours. Trp53 deletions are frequently observed in animals of Trp53 heterozygous background exposed to either Fe ions or gamma radiation. In Trp53ΔP mice, localised deletions at the Trp53 locus were only seen in tumours induced by 56Fe ions.
