Fig. 3: CD8+ T cells are required for the spontaneous control of IFN-γ-insensitive tumors. | Nature Communications

Fig. 3: CD8+ T cells are required for the spontaneous control of IFN-γ-insensitive tumors.

From: Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells

Fig. 3: CD8+ T cells are required for the spontaneous control of IFN-γ-insensitive tumors.

a Tumor outgrowth of WT, IFNγR2 Mut.1, and Jak1 Mut.2 tumors in Rag2–/– mice. n = 6 mice; data are pooled from two independent experiments. b Tumor outgrowth of WT, IFNγR2 Mut.1 CD8+ T cell-depleted mice. Mice received 200 μg of anti-CD8α (clone YTS169.4). n = 8 mice (WT and IFNγR2 Mut.1) and n = 7 mice (Jak1 Mut.1); data are pooled from two independent experiments. Results are expressed as mean ± s.e.m. Statistical significance was determined by a two-way ANOVA Bonferroni post-hoc test (a, b). *** p < 0.001.

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