Fig. 5: A complex genetic program is induced by IFN-γ signaling in tumor cells that includes PD-L1. | Nature Communications

Fig. 5: A complex genetic program is induced by IFN-γ signaling in tumor cells that includes PD-L1.

From: Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells

Fig. 5: A complex genetic program is induced by IFN-γ signaling in tumor cells that includes PD-L1.

a Volcano plot of differentially expressed genes (DEGs) from IFNγR2- and Jak1-mutant tumor cells compared to WT tumor cells. Tumor cells were sorted on day 7 after tumor engraftment. b The number of unique and shared DEGs between IFNγR2- and Jak1-mutant tumor cells. c Selected downregulated genes in IFNγR2- or Jak1-mutant tumor cells compared to WT tumor cells grouped by biological pathway. Numerical values in heat map are expressed as Z-scores.

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