Fig. 4: RNA interactions and genomic structural features. | Nature Communications

Fig. 4: RNA interactions and genomic structural features.

From: RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions

Fig. 4: RNA interactions and genomic structural features.The alternative text for this image may have been generated using AI.

a–d Metadata profiles showing the average coverage of a, b DNA tags or c, d RNA tags at the boundaries of TADs in mESCs (a, c) and mOPCs (b, d) for the indicated conditions. e, f Average RNA-binding signal at TAD boundaries in total mESCs and mOPCs, respectively. The signal was split based on whether the RNA originated within or outside of the TAD. Coverage distance from the TAD is relative to the corresponding TAD width. g, h Percentage of RNA–DNA interactions in total RADICL-seq libraries from mESCs and mOPCs, respectively, divided into incremental RNA–DNA distances and with RNA tags grouped by the identity of intersected repeat elements. NR, RNA tags not mapped on any repeat. Statistical significance was calculated with the two-tailed Student’s t test. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001. All panels were generated using significant datasets. Source data are available in the Source Data File.

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