Fig. 5: Differential analysis of chromatin accessibility.

a Accumulated barplot showing the feature distribution of reproducible peaks and consensus peaks of all six regions (reproducible X means peak found in X regions). b Heatmaps depicting enriched ATAC-seq signal around cornu Ammonis 1 (CA1)-posterior cingular gyrus (PCG) differential peaks in CA1, PCG and other cortical regions. At the top, the enriched lines showing mean values of ATAC-seq signals around the differential peaks (CA1-open and PCG-open) in CA1, PCG and other cortical regions. c Pie charts showing the counts of CA1-open peaks (left) and consensus peaks (right) overlapping with known subcortical enhancers. d Pie charts showing the counts of PCG-open peaks (left) and consensus peaks (right) overlapping with known cortical enhancers. e Barplot showing the function enrichment of the genes correlated with the CA1-open peaks (left) and PCG-open peaks (right) (Pearson’s r > 0.7, FDR < 0.1). f Genome browser view showing ATAC-seq signal and RNA-seq expression profiles around the NEUROD1 loci. The orange shadow represented the CA1-open peak that was correlated with the NEUROD1 expression. g Genome browser view showing ATAC-seq signal and RNA-seq expression profiles around the MCHR2 loci. The orange shadow represented the PCG-open peak that was correlated with the MCHR2 expression.