Fig. 8: Schematic for the contribution of hepatic EVs to adipose remodelling. | Nature Communications

Fig. 8: Schematic for the contribution of hepatic EVs to adipose remodelling.

From: Liver governs adipose remodelling via extracellular vesicles in response to lipid overload

Fig. 8: Schematic for the contribution of hepatic EVs to adipose remodelling.The alternative text for this image may have been generated using AI.

Induced Ggpps expression in hepatocytes by acute and chronic HFD consumption gives rise to hepatocyte-derived EV secretion through Rab27A geranylgeranylation, which remodels adipose tissue via adipogenesis and lipogenesis. Hepatocyte-derived EVs containing miRNAs enhance lipid deposition in adipocytes by increasing lipogenesis and inhibiting lipid oxidation through the let-7e-5p-Pgc1α axis.

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