Fig. 5: HAGGIS predicts hippocampus–brain relationships.
a From top to bottom: The spatial distribution of (smoothed) HAGGIS across samples, differential functional connectivity to the anterior vs. posterior hippocampus measured with rsfMRI, differential structural covariance with the anterior vs. posterior hippocampus, differential vulnerability to AD or FTD measured with FDG-PET. Graphs on the left visualize the relationship between these spatial patterns by comparing the HAGGIS of each sample with the mean value from the respective map within a 5-voxel cube around the sample coordinate. b Each of the above associations was re-calculated using three other brain masks, and using a HAGGIS formed from each gene set identified in the section (genes associated with the long axis of the human hippocampus in Results). The r2 of each of these associations is visualized. c Pie charts indicating the proportion of genomic and total variance explained by each model. Numbers in parentheses indicate percentage of total genomic variance. d Genes involved in both the longitudinal axis of the hippocampus, and hippocampus–brain interactions. All genes pictured are among the top 50 anterior (red; left) or posterior (blue; right) features of the hippocampus longitudinal axis model. Each also participates in one or more hippocampus–brain interactions, indicated by the circles within the Venn diagrams. FCX Differential functional connectivity between anterior and posterior hippocampus; SCX Differential structural covariance between anterior and posterior hippocampus; DIS Differential vulnerability between AD and FTD.
